TY - JOUR T1 - Glucosamine and chondroitin sulphate did not improve pain in osteoarthritis of the knee JF - Evidence Based Medicine JO - Evid Based Med SP - 115 LP - 115 DO - 10.1136/ebm.11.4.115 VL - 11 IS - 4 A2 - , Y1 - 2006/08/01 UR - http://ebm.bmj.com/content/11/4/115.abstract N2 - Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795–808.OpenUrlCrossRefPubMedWeb of Science 
 
 Q In patients with osteoarthritis of the knee, are glucosamine, chondroitin sulphate, or both more effective than placebo for relief of pain? Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★☆☆ Rheumatology ★★★★★★☆ Physical medicine & rehabilitation ★★★★★★★ Design randomised placebo controlled trial. (Glucosamine/chondroitin Arthritis Intervention Trial [GAIT]). Allocation unclear allocation concealment.* Blinding blinded (clinicians and patients).* Follow-up period 6 months. Setting 16 clinical centres in the US. Patients 1583 patients ⩾40 years of age (mean age 59 y, 54% women) who had knee pain for ⩾6 months and on most days of the previous month; radiographic evidence of osteoarthritis; score 125–400 on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC); and American Rheumatism Association functional class … ER -