TY - JOUR T1 - Review: long term use of hormone therapy by postmenopausal women does not prevent chronic diseases JF - Evidence Based Medicine JO - Evid Based Med SP - 22 LP - 22 DO - 10.1136/ebm.11.1.22 VL - 11 IS - 1 A2 - , Y1 - 2006/02/01 UR - http://ebm.bmj.com/content/11/1/22.abstract N2 - Farquhar CM, Majoribanks J, Lethaby A, et al. Long term hormone therapy for perimenopausal and postmenopausal women. Cochrane Database Syst Rev 2005;(3):CD004143. 
 
 Q In perimenopausal and postmenopausal women, does long term use of hormone therapy (HT) affect the risk of death, vascular disease, cancer, dementia, and other chronic diseases? Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Endocrine ★★★★★★☆ Geriatrics ★★★★★★☆ Gynaecology ★★★★★★★ Data sources: Medline, EMBASE/Excerpta Medica, Biological Abstracts, Cochrane Central Register of Controlled Trials, and Cochrane Menstrual Disorders and Subfertility Group Trials Register (to November 2004); UK National Research Register and registers from the UK National Health Service Centre for Reviews and Dissemination (to January 2004); reference lists of relevant articles; and pharmaceutical companies. Study selection and assessment: randomised, double blind, placebo controlled trials (RCTs) that evaluated the effect of long term HT use (⩾1 y) on death or serious chronic diseases in perimenopausal or postmenopausal women. HT consisted of oestrogen, alone or combined with progestogen, administered by oral, transdermal, subcutaneous, or intranasal routes. Outcomes: mortality, heart disease, … ER -