TY - JOUR T1 - Imiquimod 5% cream reduced lesion size in vulvar intraepithelial neoplasia JF - Evidence Based Medicine JO - Evid Based Med SP - 143 LP - 143 DO - 10.1136/ebm.13.5.143 VL - 13 IS - 5 A2 - , Y1 - 2008/10/01 UR - http://ebm.bmj.com/content/13/5/143.abstract N2 - T HelmerhorstDr T Helmerhorst, Erasmus University Medical Center, Rotterdam, The Netherlands; t.helmerhorst@erasmusmc.nlDesign:randomised placebo controlled trial.Allocation:concealed.*Blinding:blinded (patients, clinicians, outcome assessors, {data collectors, and safety committee}†).*Setting:2 academic medical centres in the Netherlands.Patients:52 women ⩾18 years of age (range 22–71 y) who had multifocal grade 2 or 3 vulvar intraepithelial neoplasia without microinvasion and used contraceptives if they were premenopausal and sexually active. Exclusion criteria included cancer or inflammatory dermatosis of the vulva, pregnancy, immunodeficiency, any treatment for vulvar intraepithelial neoplasia or warts within the previous month, and hypersensitivity to the study … ER -