TY - JOUR T1 - Review: C-reactive protein has moderate diagnostic accuracy for serious bacterial infection in children with fever JF - Evidence Based Medicine JO - Evid Based Med SP - 56 LP - 56 DO - 10.1136/ebm.14.2.56 VL - 14 IS - 2 A2 - , Y1 - 2009/04/01 UR - http://ebm.bmj.com/content/14/2/56.abstract N2 - S SandersMs S Sanders, University of Queensland, Brisbane, Queensland, Australia; s.sanders@uq.edu.auWhat is the diagnostic accuracy of C-reactive protein (CRP) for bacterial infections in children with fever?Included studies compared blood or serum CRP with a reference standard for microbiological diagnosis of bacterial v non-bacterial infection or serious bacterial v benign bacterial or non-bacterial infection in children initially presenting with fever. Excluded were studies involving >10% neonates, children admitted to hospital outside of the emergency department (ED) or with a specific medical condition (eg, cancer or renal failure), or in which the reference standard was diagnosis of a specific disease (eg, meningitis, gastroenteritis, or arthritis). Outcome measures were sensitivity, specificity, positive and negative likelihood ratios, and diagnostic odds ratio.Medline and EMBASE/Excerpta Medica … ER -