TY - JOUR T1 - Cognitive behaviour therapy reduced fatigue severity and functional impairment in chronic fatigue syndrome JF - Evidence Based Medicine JO - Evid Based Med SP - 157 LP - 157 DO - 10.1136/ebm.6.5.157 VL - 6 IS - 5 A2 - , Y1 - 2001/09/01 UR - http://ebm.bmj.com/content/6/5/157.abstract N2 - (2001) Lancet 357, 841. Prins JB, Bleijenberg G, Bazelmans E, et al.. Cognitive behaviour therapy for chronic fatigue syndrome: a multicentre randomised controlled trial.. Mar 17;. :. –7.OpenUrlCrossRefPubMedWeb of Science
 
 QUESTION: In patients with the chronic fatigue syndrome (CFS), how effective is cognitive behaviour therapy (CBT) in reducing fatigue and functional improvement? Multicentre, randomised {allocation concealed*}†, unblinded,* controlled trial with 8 months follow up (follow up at 14 mo was <80%). 3 mental health settings in the Netherlands: 2 based in university medical centres and 1 in a mental health institute. 278 patients between 18 and 60 years of age (mean age 37 y, 79% women) with the US Centers for Disease Control and Prevention criteria for CFS, a score of ≥40 on the fatigue severity subscale of the checklist individual strength (CIS), and a score of ≥800 on the sickness impact profile. Exclusion criteria included pregnancy and previous or current participation in CFS research. 93 patients were allocated to CBT (sixteen 1 h sessions over 8 mo), 94 to guided support groups (eleven 1.5 h meetings over 8 mo), and 91 to the control … ER -