TY - JOUR T1 - Review: antidepressants are effective for clinical improvement in unexplained physical symptoms and syndromes JF - Evidence Based Medicine JO - Evid Based Med SP - 143 LP - 143 DO - 10.1136/ebm.5.5.143 VL - 5 IS - 5 A2 - , Y1 - 2000/09/01 UR - http://ebm.bmj.com/content/5/5/143.abstract N2 - (1999) J Fam Pract. 48, 980. O'Malley PG, Jackson JL, Santoro J, et al.. Antidepressant therapy for unexplained symptoms and symptom syndromes.. Dec;. :. –90.OpenUrlPubMedWeb of Science
 
 QUESTION: In adults who have medically unexplained physical symptoms (MUPS), do antidepressants improve outcomes? Studies were identified by searching Medline (1966–98), PsycLIT (1974–98), EMBASE/Excerpta Medica (1974–98), the Cochrane Library, the Federal Research in Progress database, and bibliographies of relevant articles. 2 reviewers independently selected studies that were randomised controlled trials (RCTs) (including crossover trials), involved adults with MUPS, compared antidepressants with placebo or a non-antidepressant intervention, reported measurable outcomes, and were published in English. Data extracted included symptoms, setting, treatment (regimens and follow up), patient characteristics, assessment of comorbid psychiatric disease, adverse effects, outcomes, statistical analysis of reported results, and quality of study methods (Jadad scale). 94 RCTs on 6 symptom syndromes met the selection criteria. 6595 patients … ER -