TY - JOUR T1 - Cisapride was effective in the short term for constipation in children JF - Evidence Based Medicine JO - Evid Based Med SP - 150 LP - 150 DO - 10.1136/ebm.5.5.150 VL - 5 IS - 5 A2 - , Y1 - 2000/09/01 UR - http://ebm.bmj.com/content/5/5/150.abstract N2 - (2000) J Pediatr 136, 35. Nurko S, Garcia-Aranda JA, Worona LB, et al.. Cisapride for the treatment of constipation in children: a double-blind study.. Jan;. :. –40.OpenUrlCrossRefPubMedWeb of Science
 
 QUESTION: In children with constipation, what is the effectiveness of cisapride (a prokinetic agent)? 12 week randomised (allocation concealed*), blinded {clinicians, patients, outcome assessors, and statisticians}†* placebo controlled trial. Gastroenterology clinic of a hospital in Mexico City, Mexico. 40 children who were 2–16 years of age, had a history of chronic constipation, and had <3 bowel movements per week during a 2 week observation period before enrolment. Exclusion criteria were Hirschsprung disease, other congenital abnormalities of the gastrointestinal tract, or pelvic floor dyssynergia. Data were available for 36 patients (90%) (mean age 6 y, 67% boys). Patients were disimpacted and allocated to cisapride (n=17) or placebo (n=19) for 12 weeks. The medications were given as an oral suspension, 0.2 mg/kg of body weight per … ER -