TY - JOUR T1 - Meta-analysis of RCTs finds that increasing consumption of polyunsaturated fat as a replacement for saturated fat reduces the risk of coronary heart disease JF - Evidence Based Medicine JO - Evid Based Med SP - 108 LP - 109 DO - 10.1136/ebm1093 VL - 15 IS - 4 AU - Lee Hooper Y1 - 2010/08/01 UR - http://ebm.bmj.com/content/15/4/108.abstract N2 - Commentary on: Mozaffarian D, Micha R, Wallace S. Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials. PLoS Med 2010;7:e1000252. Saturated fat consumption tends to increase circulation of low-density lipoprotein which in turn increases the risk of cardiovascular disease. Debate continues on how to replace the energy lost in reducing saturated fat – should we replace this energy with carbohydrate, protein or fat, and if fat, what type? Mozaffarian and colleagues aimed to address this question by systematically reviewing the effects on myocardial infarction and coronary death of partly replacing saturated fat intake by ω-6 polyunsaturated fatty acids (PUFA), including randomised controlled trials that continued for at least 12 months. This systematic review is a useful and thoughtful attempt to address this important question, and its methods are generally highly appropriate. The exception is the searching for, and inclusion of, appropriate trials. The mainstay of a systematic review is to find and assess all relevant studies, often … ER -