TY - JOUR T1 - Prenatal and postnatal administration of <em>Lactobacillus</em> GG reduced the occurrence of atopic disease in offspring JF - Evidence Based Medicine JO - Evid Based Med SP - 178 LP - 178 DO - 10.1136/ebm.6.6.178 VL - 6 IS - 6 A2 - , Y1 - 2001/11/01 UR - http://ebm.bmj.com/content/6/6/178.abstract N2 - (2001) Lancet 357, 1076; Kalliomäki M, Salminen S, Arvilommi H, et al.. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial.. Apr 7;. :. –9.OpenUrlCrossRefPubMedWeb of Science
 
 QUESTION: In offspring at risk for atopic disease, does oral administration of Lactobacillus GG (LGG), given prenatally to mothers and postnatally to their infants, prevent atopic eczema? Randomised (unclear allocation concealment*), blinded (clinicians, patients, and outcome assessors),*) controlled trial with 2 years of follow up. Antenatal clinics in Turku, Finland. 159 pregnant women who had atopic disease, or ≥ 1 first-degree relative (mother, father, or older sibling), or partner with atopic eczema, allergic rhinitis, or asthma. 132 women (83%) and 132 children completed follow up. Mothers were allocated to LGG (1 × 1010 colony-forming units [Valio Limited, Helsinki, Finland]) (n=77) or to placebo (microcrystalline cellulose) (n=82). The capsules were taken daily for 2 to 4 weeks before expected delivery. After delivery, … ER -