TY - JOUR T1 - Glyburide was as safe and effective as insulin in gestational diabetes JF - Evidence Based Medicine JO - Evid Based Med SP - 79 LP - 79 DO - 10.1136/ebm.6.3.79 VL - 6 IS - 3 A2 - , Y1 - 2001/05/01 UR - http://ebm.bmj.com/content/6/3/79.abstract N2 - (2000) N Engl J Med 343, 1134. Langer O, Conway DL, Berkus MD, et al.. A comparison of glyburide and insulin in women with gestational diabetes mellitus.. Oct 19;. :. –8..OpenUrlCrossRefPubMedWeb of Science
 
 QUESTION: Is glyburide as effective and safe as insulin in women with gestational diabetes mellitus? Randomised (allocation concealed*), unblinded,* controlled trial. Maternal health clinics in San Antonio, Texas, USA. 404 women (mean age 29.5 y) who were between 11 and 33 weeks of gestation with a singleton pregnancy and who had gestational diabetes and fasting blood glucose concentrations ≥5.3 mmol/l and <7.8 mmol/l. Follow up was 100%. 404 women were allocated to receive glyburide (n=201) or insulin (n=203). Glyburide was started at an oral dose of 2.5 mg and increased to 20 mg as needed. Insulin was started at a dose of 0.7 U/kg of actual body weight, given subcutaneously 3 times/day, and increased as needed. … ER -