TY - JOUR T1 - Review: twice daily dosing of penicillin V is as effective as more frequent dosing for streptococcal tonsillopharyngitis JF - Evidence Based Medicine JO - Evid Based Med SP - 168 LP - 168 DO - 10.1136/ebm.5.6.168 VL - 5 IS - 6 A2 - , Y1 - 2000/11/01 UR - http://ebm.bmj.com/content/5/6/168.abstract N2 - . Lan AJ, Colford JM Jr. The impact of dosing frequency on the efficacy of 10-day penicillin or amoxicillin therapy for streptococcal tonsillopharyngitis: a meta-analysis. Pediatrics 2000 Feb;105:E19..
 
 QUESTION: In patients with acute group A β-haemolytic streptococcal (GABHS) tonsillopharyngitis, is once or twice daily dosing of penicillin or amoxicillin less effective than dosing 3 (TID) or 4 (QID) times daily? Studies were identified by searching Medline and Dissertation Abstracts (to August 1998), abstracts of the annual Interscience Conference on Antimicrobial Agents and Chemotherapy (1983 to 1997), and bibliographies of relevant articles. Studies were selected if they were randomised controlled trials (RCTs) that compared different dosing frequencies of 10 day oral penicillin or amoxicillin while keeping the same total daily dose, based the diagnosis of acute GABHS tonsillopharyngitis on symptoms and positive throat culture results or positive antigen detection test results, and began antibiotic treatment at the time of … ER -