TY - JOUR T1 - Targeting postprandial blood glucose concentrations reduced haemoglobin A<sub>1c</sub> concentrations in type 2 diabetes mellitus JF - Evidence Based Medicine JO - Evid Based Med SP - 80 LP - 80 DO - 10.1136/ebm.6.3.80 VL - 6 IS - 3 A2 - , Y1 - 2001/05/01 UR - http://ebm.bmj.com/content/6/3/80.abstract N2 - (2000) Diabetes Care 23, 1236. Bastyr EJ 3d, Stuart CA, Brodows RG, et al,. for the IOEZ Study Group.. Therapy focused on lowering postprandial glucose, not fasting glucose, may be superior for lowering HbA. 1c. . . Sep;. :. –41.OpenUrlAbstract/FREE Full Text
 
 QUESTION: What is the comparative efficacy and safety of treatment strategies that target either fasting, premeal, or postprandial glucose concentrations in patients with type 2 diabetes mellitus that was not adequately controlled with sulfonylurea agents alone? Randomised {allocation concealed*}†, unblinded,* controlled trial with 3 months of follow up. 22 centres in the US. 135 patients (mean age 57 y, 60% men) with type 2 diabetes who had secondary sulfonylurea failure defined as initial stabilisation of glucose control for ≥6 months and a subsequent lack of glucose control using maximal sulfonylurea doses. 114 patients (84%) had complete follow up. Patients were allocated to 1 of 3 groups for 3 months: insulin lispro plus glyburide (L plus G group, n=41), which targeted postprandial blood glucose concentrations; metformin plus glyburide (M plus G group, … ER -