TY - JOUR T1 - Review: misoprostol, double dose H<sub>2</sub> receptor antagonists, and proton pump inhibitors reduce GI ulcers in long term NSAID use JF - Evidence Based Medicine JO - Evid Based Med SP - 88 LP - 88 DO - 10.1136/ebm.6.3.88 VL - 6 IS - 3 A2 - , Y1 - 2001/05/01 UR - http://ebm.bmj.com/content/6/3/88.abstract N2 - (2000) Cochrane Database Syst Rev 2000;(4):CD002296 (latest version 21 Aug 2000) (also published in J Rheumatol 27, 2203; Rostom A, Wells G, Tugwell P, et al.. Prevention of NSAID–induced gastroduodenal ulcers.. ;. :. –14).
 
 QUESTION: In patients requiring long term non-steroidal anti-inflammatory drugs (NSAIDs), are prostaglandin analogues (PAs), H2 receptor antagonists (H2RAs), and proton pump inhibitors (PPIs) effective at reducing NSAID induced gastrointestinal (GI) ulcers? Studies were identified by searching Medline (1966 to January 2000) and EMBASE/Excerpta Medica (to February 1999), the Cochrane Controlled Trials Register (1973–99), current contents (6 mo before January 2000), and conference proceedings; by reviewing bibliographies of retrieved studies, including reviews; and through personal contact with experts and companies. 2 reviewers independently selected randomised controlled trials published in any language. Studies were selected if they examined PA, H2RA, or PPI effects on preventing NSAID induced upper GI toxicity in adults; if the duration of NSAID exposure was &gt;3 weeks; and if endoscopic ulcers were ≥3 mm in … ER -