TY - JOUR T1 - Faecal occult blood screening reduced the incidence of colorectal cancer JF - Evidence Based Medicine JO - Evid Based Med SP - 89 LP - 89 DO - 10.1136/ebm.6.3.89 VL - 6 IS - 3 A2 - , Y1 - 2001/05/01 UR - http://ebm.bmj.com/content/6/3/89.abstract N2 - (2000) N Engl J Med 343, 1603. Mandel JS, Church TR, Bond JH, et al.. The effect of fecal occult-blood screening on the incidence of colorectal cancer.. Nov 30;. :. –7.OpenUrlCrossRefPubMedWeb of Science
 
 QUESTION: Does faecal occult blood screening reduce the incidence of colorectal cancer? Randomised {allocation concealed*}†, unblinded,* controlled trial with 18 years follow up. Minnesota, USA. 46 551 participants who were 50–80 years of age (52% women) and did not have a previous diagnosis of colorectal cancer. Follow up for vital status was 91% at 18 years. Participants were allocated to annual screening (n=15 532), biennial screening (n=15 550), or usual care (n=15 363). For each screening, which was done from 1976–82 and from 1986–92, participants prepared 2 guaiac impregnated paper slides for each of 3 consecutive stools. The mean rate of compliance was 75% in the annual screening group and 78% in the biennial screening group. Participants with ≥1 positive slide had a … ER -