TY - JOUR T1 - Conventional and newer antihypertensive drugs had similar efficacy in elderly people with hypertension JF - Evidence Based Medicine JO - Evid Based Med SP - 85 LP - 85 DO - 10.1136/ebm.5.3.85 VL - 5 IS - 3 A2 - , Y1 - 2000/05/01 UR - http://ebm.bmj.com/content/5/3/85.abstract N2 - (1999) Lancet 354, 1751. Hansson L, Lindholm LH, Ekbom T, et al,. for the STOP-Hypertension-2 study group.. Randomised trial of old and new antihypertensive drugs in elderly patients: cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 study.. Nov 20;. :. –6.OpenUrlCrossRefPubMedWeb of Science
 
 QUESTION: In elderly people with hypertension, are newer antihypertensive drugs as effective as conventional antihypertensive drugs for reducing cardiovascular events? Randomised {allocation concealed*}†, blinded (outcome assessors),* controlled trial with 4 year follow up. 312 health centres in Sweden. 6614 patients who were 70 to 84 years of age (mean age 76 y, 67% women) and had hypertension (defined as systolic blood pressure ≥180 mm Hg or diastolic blood pressure ≥105 mm Hg or both). Follow up was 100%. Patients were allocated to 1 of 3 groups: conventional antihypertensive drugs (atenolol, 50 mg/d; metoprolol, 100 mg/d; pindolol, 5 mg/d; or fixed ratio hydrochlorothiazide, 25 mg/d, and amiloride, 2.5 mg/d) (n=2213); angiotensin converting enzyme (ACE) … ER -