TY - JOUR T1 - Review: small treatment effect of disodium cromoglycate in childhood asthma is tempered by methodological flaws and publication bias JF - Evidence Based Medicine JO - Evid Based Med SP - 106 LP - 106 DO - 10.1136/ebm.6.4.106 VL - 6 IS - 4 A2 - , Y1 - 2001/07/01 UR - http://ebm.bmj.com/content/6/4/106.abstract N2 - (2000) Thorax 55, 913. Tasche MJ, Uijen JH, Bernsen RM, et al.. Inhaled disodium cromoglycate (DSCG) as maintenance therapy in children with asthma: a systematic review. . . Nov;. :. –20..OpenUrlAbstract/FREE Full Text
 
 QUESTION: In children with asthma, how effective is inhaled disodium cromoglycate (DSCG)? Studies were identified by searching Medline, EMBASE/Excerpta Medica, the Cochrane Controlled Trials Register, and the database of the manufacturers of DSCG with the terms asthma, sodium cromoglycate, and clinical trial. Bibliographies of relevant studies were reviewed. English language studies were selected if they were randomised, double blind, placebo controlled trials of inhaled DSCG in the maintenance treatment of asthma in children up to 18 years of age. Studies of exercise induced asthma were excluded. Data were extracted on methodological quality, setting, design, DSCG dose and method of administration, patient characteristics, duration of intervention, outcomes, and adverse effects. Symptom scores were calculated separately for wheeze and cough. Pooled estimates … ER -