TY - JOUR T1 - Combination therapy with candesartan and lisinopril was more effective than monotherapy in type 2 diabetes and hypertension JF - Evidence Based Medicine JO - Evid Based Med SP - 109 LP - 109 DO - 10.1136/ebm.6.4.109 VL - 6 IS - 4 A2 - , Y1 - 2001/07/01 UR - http://ebm.bmj.com/content/6/4/109.abstract N2 - (2000) BMJ 321, 1440. Mogensen CE, Neldam S, Tikkanen I, et al.. for the CALM Study Group. Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) study.. Dec 9;. :. –4.OpenUrlAbstract/FREE Full Text
 
 QUESTION: What are the effects of candesartan or lisinopril, or both, on blood pressure and the urinary albumin excretion rate in patients with hypertension, microalbuminuria, and type 2 diabetes mellitus? Randomised (unclear allocation concealment*), double blind (investigators and patients),* controlled trial with 24 weeks follow up. 37 centres in tertiary hospitals and primary care sites (12 in Australia, 9 in Denmark, 4 in Finland, and 12 in Israel). 199 patients between 30 and 75 years of age with type 2 diabetes, microalbuminuria (urinary albumin to creatinine ratio between 2.5 and 25 mg/mmol), and diastolic blood pressure (BP) between 90 and 110 mm Hg while receiving placebo. Exclusion criteria included body mass index ≥40 kg/m2, systolic BP >200 mm Hg, non-diabetic cause of secondary hypertension, cardiovascular event in the previous 6 months, increased serum creatinine and potassium concentrations, and haemoglobin A1c concentrations >10%. 197 patients (99%) (mean age 60 y, 65% … ER -