TY - JOUR T1 - Multicomponent comprehensive care was as effective as usual care for decreasing major bleeding in older patients on warfarin JF - Evidence Based Medicine JO - Evid Based Med SP - 116 LP - 116 DO - 10.1136/ebm.6.4.116 VL - 6 IS - 4 A2 - , Y1 - 2001/07/01 UR - http://ebm.bmj.com/content/6/4/116.abstract N2 - (2000) Ann Intern Med 133, 687. Beyth RJ, Quinn L, Landefeld CS.. A multicomponent intervention to prevent major bleeding complications in older patients receiving warfarin. A randomized, controlled trial.. Nov 7;. :. –95..OpenUrlCrossRefPubMedWeb of Science
 
 QUESTION: In older patients requiring warfarin, is multicomponent comprehensive care (MCC) more effective than usual care for reducing major bleeding events? Randomised {allocation concealed*}†, blinded (data collectors and outcome assessors),* controlled trial with 6 months follow up. Cuyahoga County, Ohio, USA. 325 patients (mean age 75 y, 57% women) who were ≥ 65 years of age, received ≥10 000 units of intravenous unfractionated heparin, resided in the area, and had planned warfarin treatment for ≥10 days. Exclusion criteria included treatment with warfarin in the previous 6 months, admission from a nursing home, or enrolment in another clinical trial. Follow up was complete. 163 patients were allocated to MCC, which consisted of a guideline based consultation and patient education, coaching, and self monitoring of prothrombin time with a portable monitor. Home visits were made 3 days after discharge to assess the patients' ability … ER -