TY - JOUR T1 - Review: lower doses of antidepressant drugs are effective and have fewer adverse effects in depression JF - Evidence Based Medicine JO - Evid Based Med SP - 22 LP - 22 DO - 10.1136/ebm.5.1.22 VL - 5 IS - 1 A2 - , Y1 - 2000/01/01 UR - http://ebm.bmj.com/content/5/1/22.abstract N2 - (1999) Br J Psychiatry 174, 297. Bollini P, Pampallona S, Tibaldi G, et al.. Effectiveness of antidepressants. Meta-analysis of dose-effect relationships in randomised clinical trials.. Apr;. :. –303.OpenUrlAbstract/FREE Full Text
 
 Questions In patients with depression, are high doses of antidepressants more effective than low doses, and how is safety affected? Studies were identified by searching Medline, Current Contents, and the Cochrane Collaboration Register of Trials; scanning the bibliographies of retrieved articles; and contacting authors. Randomised controlled trials were selected if they compared 2 different doses of the same antidepressant drug in patients with depression (>5 patients per treatment group) who were followed for at least 3 weeks. Data were extracted on patient characteristics, treatment type, number of patients clinically improved (defined as a reduction of >50% of the total score on the Hamilton Rating Scale for Depression, moderate to marked improvement on the Clinical Global Impression Scale, or lack of relapse of depressive episode), and total number of side effects. All … ER -