TY - JOUR T1 - High dose lisinopril was more effective than low dose for reducing combined mortality and cardiovascular events in congestive heart failure JF - Evidence Based Medicine JO - Evid Based Med SP - 110 LP - 110 DO - 10.1136/ebm.5.4.110 VL - 5 IS - 4 A2 - , Y1 - 2000/07/01 UR - http://ebm.bmj.com/content/5/4/110.abstract N2 - (1999) Circulation 100, 2312. Packer M, Poole-Wilson PA, Armstrong PW. , et al, on behalf of the ATLAS Study Group. . Comparative effects of low and high doses of the angiotensin-converting enzyme inhibitor, lisinopril, on morbidity and mortality in chronic heart failure.. Dec 7;. :. –8..OpenUrlAbstract/FREE Full Text
 
 QUESTION: In patients with congestive heart failure (CHF), is high dose lisinopril more effective than low dose lisinopril for reducing mortality and admission to hospital rates? Randomised (allocation concealment unclear*), blinded (patients, investigators, and outcome assessors),* controlled trial with 3 year follow up. 287 hospitals in 19 countries. 3793 patients were screened, and 3164 (mean age 63.6 y, 80% men) were studied. Inclusion criteria were New York Heart Association class II, III, or IV CHF, despite use of diuretics for ≥2 months, and left ventricular ejection fraction ≤30%. Exclusion criteria were recent revascularisation procedure or ischaemic event, history of ventricular tachycardia, intolerance to angiotensin converting enzyme (ACE) inhibitors, serum creatinine levels >2.5 mg/dl, or non-cardiac disorders that could limit survival. Follow up was 100%. Patients received their usual CHF medications … ER -