TY - JOUR T1 - The <sup>13</sup>C-urea blood test is accurate for detecting Helicobacter pylori infection JF - Evidence Based Medicine JO - Evid Based Med SP - 31 LP - 31 DO - 10.1136/ebm.5.1.31 VL - 5 IS - 1 A2 - , Y1 - 2000/01/01 UR - http://ebm.bmj.com/content/5/1/31.abstract N2 - (1999) 13C-urea blood test accurately detects active Helicobacter pylori infection: a United States, multicenter trial. Am J Gastroenterol. 94, 1522; Chey WD, Murthy U, Toskes P, et al.. The . Jun;. :. –4.
 
 QUESTION: How accurate is the 13C-urea blood test for detecting Helicobacter pylori infection? Blinded comparison of the 13C-urea blood test with tests based on endoscopic biopsy. 5 centres in the United States (Ann Arbor, Michigan; Syracuse, New York; Gainesville, Florida; Savannah, Georgia; and Los Angeles, California). 121 patients (mean age 49 y, 51% men) who were referred for endoscopy. Exclusion criteria included treatment for H. pylori infection in the previous year or use of antibiotics or bismuth in the previous month or proton-pump inhibitors in the previous 7 days. Patients received 13C-urea, 125 mg dissolved in 75 ml of water. 30 minutes later, a 3-ml blood sample was obtained by venipuncture and analysed by gas isotope ratio mass spectrometry. The 3 diagnostic standards were histological evidence of H. pylori infection in biopsies obtained from the body and antrum of the stomach, a positive result for both histological and rapid urease … ER -