TY - JOUR T1 - In people with subclinical hypothyroidism, TSH level >10 mIU/l may predict increased risk of coronary heart disease and related mortality JF - Evidence Based Medicine JO - Evid Based Med SP - 31 LP - 32 DO - 10.1136/ebm1166 VL - 16 IS - 1 AU - Elizabeth N Pearce Y1 - 2011/02/01 UR - http://ebm.bmj.com/content/16/1/31.abstract N2 - Commentary on: Rodondi N, den Elzen WP, Bauer DC, et al.; Thyroid Studies Collaboration. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA 2010;304:1365–74.OpenUrlCrossRefPubMedWeb of Science Subclinical hypothyroidism, defined as an elevated thyroid-stimulating hormone (TSH) level with normal peripheral free thyroid hormone values, is highly prevalent, occurring in 4–10% of adults.1 Observational studies have identified associations between subclinical hypothyroidism and hyperlipidaemia and other atherosclerosis risk factors. However, it has been unclear whether subclinical hypothyroidism is associated with an increased risk for cardiovascular events and mortality. Results of several longitudinal studies and three previous study-level meta-analyses2,–,4 have been inconsistent. Individual-level meta-analyses had not previously been performed. Rodondi and colleagues used a systematic literature search in all languages to identify potential studies for inclusion in a meta-analysis. MEDLINE and EMBASE databases and searches of key article bibliographies were used to identify articles describing associations between subclinical thyroid … ER -