TY - JOUR T1 - Reduced sodium intake lowered blood pressure and need for antihypertensive medication JF - Evidence Based Medicine JO - Evid Based Med SP - 151 LP - 151 DO - 10.1136/ebm.6.5.151 VL - 6 IS - 5 A2 - , Y1 - 2001/09/01 UR - http://ebm.bmj.com/content/6/5/151.abstract N2 - (2001) Arch Intern Med 161, 685. Appel LJ, Espeland MA, Easter L, et al.. Effects of reduced sodium intake on hypertension control in older individuals. Results from the Trial of Nonpharmacologic Interventions in the Elderly (TONE).. Mar 12;. :. –93.OpenUrlCrossRefPubMedWeb of Science
 
 QUESTION: In older adults with hypertension, is a reduced dietary sodium (RS) intervention more effective than usual lifestyle (UL) in controlling blood pressure and preventing cardiovascular events? Randomised {allocation concealed*}†, blinded (outcome assessors),* controlled trial with 30 months follow up. 4 clinical centres in the US. 681 patients who were 60–80 years of age (mean age 66 y, 53% men) and had systolic blood pressure (SBP) <145 mm Hg and diastolic blood pressure (DBP) <85 mm Hg while taking 1 antihypertensive medication (AM). Exclusion criteria were use of AM for conditions other than hypertension, myocardial infarction (MI) or stroke in the previous 6 months, angina pectoris, congestive heart failure (CHF), serum creatinine concentration >176.8 μmol/l, blood glucose concentration >14.4 mmol/l, or average alcohol intake >14 drinks per week. Follow … ER -