TY - JOUR T1 - Permethrin (PER) plus trimethoprim/sulfamethoxazole (TMP/SMX) was better than PER but not TMP/SMX for head lice infestation in children JF - Evidence Based Medicine JO - Evid Based Med SP - 152 LP - 152 DO - 10.1136/ebm.6.5.152 VL - 6 IS - 5 A2 - , Y1 - 2001/09/01 UR - http://ebm.bmj.com/content/6/5/152.abstract N2 - (2001) Pediatrics 107, E30. Hipolito RB, Mallorca FG, Zuniga-Macaraig ZO, et al. . Head lice infestation: single drug versus combination therapy with one percent permethrin and trimethoprim/sulfamethoxazole.. Mar;. :. ..OpenUrlCrossRefPubMed
 
 QUESTION: Is a combination of topical permethrin (PER) and oral trimethoprim/sulfamethoxazole (TMP/SMX) better than either PER or TMP/SMX alone for treating head lice infestation (HLI)? Randomised (unclear allocation concealment*), blinded (unclear),* controlled trial with 4 weeks follow up. 3 private paediatric and family practices in San Joaquin County, California, USA. 115 children who were 2–13 years of age (70% girls) and were diagnosed with HLI (clinical suspicion of lice or eggs). Children with hypersensitivity to TMP/SMX or 1% PER or with a history of parental non-compliance or neglect were excluded from the study. 97% of children completed follow up. In all treatment groups, parents were instructed to first wash their child's hair with regular shampoo and then rinse. 39 children were allocated to 1% PER, for which parents were … ER -