TY - JOUR T1 - Review: probiotics are effective in preventing antibiotic-associated diarrhoea JF - Evidence Based Medicine JO - Evid Based Med SP - 184 LP - 184 DO - 10.1136/ebm.7.6.184 VL - 7 IS - 6 A2 - , Y1 - 2002/11/01 UR - http://ebm.bmj.com/content/7/6/184.abstract N2 - (2002) BMJ 324, 1361; D’Souza AL, Rajkumar C, Cooke J, et al.. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis.. Jun 8;. :. –4..OpenUrlAbstract/FREE Full Text
 
 QUESTION: In patients being treated with antibiotics, does co-administration of probiotics reduce the incidence of diarrhoea? Studies in any language (with English abstracts) were identified by searching Medline (1966–2000) with the terms probiotics, biotherapeutic agents, lactobacilli, antibiotic associated diarrhoea, and Clostridium difficile; the Cochrane Controlled Trials Register; and the Cochrane Database of Systematic Reviews. Studies were selected if they were randomised, double-blind, placebo-controlled trials of probiotic treatment given in combination with antibiotics and diarrhoea prevention was reported. Data were extracted on sample size; type, dose, and duration of probiotic treatment; and antibiotic studied. The outcome of interest was prevention of diarrhoea. Diarrhoea was defined … ER -