TY - JOUR T1 - Review: one tenth of patients with Crohn’s disease have prolonged remission JF - Evidence Based Medicine JO - Evid Based Med SP - 190 LP - 190 DO - 10.1136/ebm.7.6.190 VL - 7 IS - 6 A2 - , Y1 - 2002/11/01 UR - http://ebm.bmj.com/content/7/6/190.abstract N2 - (2002) Aliment Pharmacol Ther 16, 51; Loftus EV, Jr, Schoenfeld P, Sandborn WJ.. The epidemiology and natural history of Crohn’s disease in population-based patient cohorts from North America: a systematic review.. Jan;. :. –60..OpenUrlCrossRefPubMedWeb of Science
 
 QUESTION: In patients with Crohn’s disease, what is the natural history of the disease? Studies were identified by searching Medline, Current Contents (1966 to September 2000), and bibliographies of relevant studies. 2 reviewers independently selected fully published English language trials that were population-based studies of patients followed from the time of initial diagnosis; used appropriate and objective criteria for disease; had sufficiently long and complete follow up; and quantified disease activity, medication use, and surgery. 2 reviewers independently and blindly extracted data on disease severity or activity, use of medication, and surgical resection rates. Disagreements were resolved by consensus. 3 studies of 1 population-based cohort (225 people followed from 1940–93) met the selection criteria for natural history studies. 1 study showed that a representative patient spent 24% of … ER -