TY - JOUR T1 - Antioxidant vitamins did not reduce death, vascular events, or cancer in high risk patients JF - Evidence Based Medicine JO - Evid Based Med SP - 11 LP - 11 DO - 10.1136/ebm.8.1.11 VL - 8 IS - 1 A2 - , Y1 - 2003/01/01 UR - http://ebm.bmj.com/content/8/1/11.abstract N2 - (2002) Lancet 360, 23; MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20 536 high-risk individuals: a randomised placebo-controlled trial.. ;. :. –33..OpenUrlCrossRefPubMedWeb of Science
 
 QUESTION: In patients with a high 5 year risk of death, does antioxidant supplementation reduce death, vascular events, and cancer? Randomised (allocation concealed*), blinded (participants, clinicians, data collectors, and outcome assessors),* placebo controlled trial with mean follow up of 5 years. 69 UK hospitals. 20 536 patients who were 40–80 years of age (28% were ≥ 70 y of age, 75% men); had nonfasting total cholesterol levels ≥3.5 mmol/l; and had a substantial 5 year risk of death because of a history of coronary heart disease (CHD), occlusive disease of noncoronary arteries, or diabetes mellitus or a history of treated hypertension (in men ≥65 y of age). Exclusion criteria included a clear indication for statin therapy according to the patient‘s doctor, abnormal liver or renal function, severe heart failure, severe chronic airway disease, cancer, and indication for high dose vitamin E supplements. Follow up was 99.7%. Patients received 2 months of active vitamins during a run … ER -