TY - JOUR T1 - Long term oestrogen plus progestin increased venous thromboembolism and biliary tract surgery in postmenopausal women JF - Evidence Based Medicine JO - Evid Based Med SP - 13 LP - 13 DO - 10.1136/ebm.8.1.13 VL - 8 IS - 1 A2 - , Y1 - 2003/01/01 UR - http://ebm.bmj.com/content/8/1/13.abstract N2 - (2002) JAMA. 288, 58; Hulley S, Furberg C, Barrett-Connor E. , et al., for the HERS Research Group. . Noncardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/Progestin Replacement Study follow-up (HERS II).. ;. :. –66..OpenUrlCrossRefPubMedWeb of Science
 
 QUESTION: In postmenopausal women with established coronary heart disease (CHD), what is the effect of oestrogen plus progestin on the risks of common non cardiovascular disease outcomes after 6.8 years of follow up? Randomised (allocation concealed*), placebo controlled trial. The study was blinded (patients, investigators, and outcome assessors)* for the initial mean 4.1 years of follow up and unblinded* for the subsequent mean 2.7 years of follow up (the latter 2.7 years was the HERS II study). 20 US outpatient and community centres. 2763 postmenopausal women <80 years of age (mean age 67 y) with established CHD who had not had a hysterectomy. Exclusion criteria included deep venous thrombosis, pulmonary embolism, breast cancer, endometrial hyperplasia or cancer, abnormal Papanicolaou result, hormone use in the previous 3 months, and life threatening disease. Of those alive at 4.1 years, (n=2510), follow up was 84% at … ER -