TY - JOUR T1 - Review: β blockers increase fatigue and sexual dysfunction but not depression after myocardial infarction JF - Evidence Based Medicine JO - Evid Based Med SP - 15 LP - 15 DO - 10.1136/ebm.8.1.15 VL - 8 IS - 1 A2 - , Y1 - 2003/01/01 UR - http://ebm.bmj.com/content/8/1/15.abstract N2 - (2002) JAMA. 288, 351; Ko DT, Hebert PR, Coffey CS, et al. . β. -blocker therapy and symptoms of depression, fatigue, and sexual dysfunction.. ;. :. –7..OpenUrlCrossRefPubMedWeb of Science
 
 QUESTION: In patients who have had myocardial infarction, heart failure, or hypertension, do β blockers increase depressive symptoms, fatigue, and sexual dysfunction? Studies were identified by searching Medline (1966–2001) with the keywords myocardial infarction, heart failure, or hypertension in combination with the keywords adrenergic β antagonists and trial; and by scanning reference lists. English language studies were selected if they were randomised controlled trials with a placebo comparison, were not crossover trials, enrolled ≥100 patients, and had ≥6 months of follow up. Data were extracted on number of patients; presence of heart failure, hypertension, or myocardial infarction; length of follow up; type of β blocker; and patient reported adverse events (ie, depressive symptoms, fatigue, … ER -