TY - JOUR T1 - Lansoprazole reduced recurrence of ulcer complications in long term use of low dose aspirin JF - Evidence Based Medicine JO - Evid Based Med SP - 19 LP - 19 DO - 10.1136/ebm.8.1.19 VL - 8 IS - 1 A2 - , Y1 - 2003/01/01 UR - http://ebm.bmj.com/content/8/1/19.abstract N2 - (2002) N Engl J Med 346, 2033; Lai KC, Lam SK, Chu KM, et al.. Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use.. ;. :. –8.OpenUrlCrossRefPubMedWeb of Science
 
 QUESTION: In patients receiving continuous treatment with low dose aspirin, is Helicobacter pylori eradication plus lansoprazole more effective than H pylori eradication alone for preventing the recurrence of ulcer complications? Randomised {allocation concealed*}†, blinded (clinicians, patients, outcome assessors, monitoring committee, and data analysts),* placebo controlled trial with a median follow up of 12 months. A university hospital in Hong Kong, China. 123 patients who were 18–80 years of age (mean age 70 y, 72% men) and had ulcers (gastric, duodenal, or gastroduodenal), were receiving low dose aspirin for >1 month before developing ulcers, had a disease such as stroke or ischaemic heart disease that required long term continuous treatment with low dose aspirin, and had H pylori infection … ER -