TY - JOUR T1 - White matter changes, creatinine, age, and ankle arm index predicted incident MRI defined infarctions in older adults JF - Evidence Based Medicine JO - Evid Based Med SP - 121 LP - 121 DO - 10.1136/ebm.8.4.121 VL - 8 IS - 4 A2 - , Y1 - 2003/07/01 UR - http://ebm.bmj.com/content/8/4/121.abstract N2 - (2002) Stroke 33, 2376. Longstreth WT Jr, Dulberg C, Manolio TA, et al.. Incidence, manifestations, and predictors of brain infarcts defined by serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study.. ;. :. –82.OpenUrlAbstract/FREE Full Text
 
 QUESTION: In older adults whose baseline magnetic resonance imaging (MRI) scan showed no infarctions, what are predictors of infarctions defined by serial cranial MRI? Cohort study with mean and median follow up of 5 years (range 3.2–7.5 y). 4 communities in North Carolina, California, Maryland, and Pennsylvania, USA. 1433 adults ≥65 years of age with no infarctions shown on baseline MRI scan who were able to give informed consent and to respond to questions without the aid of a surrogate respondent. Baseline data on blood pressure, ankle arm index, cognitive function, activities of daily living (ADL), instrumental ADL, and depression were collected by questionnaires, physical examination, and laboratory tests. Incident infarction defined by follow up serial cranial MRI scan, identified by neuroradiologists blinded to participants' clinical information. On the follow up MRI scan, 254 participants (18%) had ≥1 … ER -