TY - JOUR T1 - Postexposure prophylaxis with oseltamivir reduced influenza transmission in households JF - Evidence Based Medicine JO - Evid Based Med SP - 142 LP - 142 DO - 10.1136/ebm.9.5.142 VL - 9 IS - 5 A2 - , Y1 - 2004/09/01 UR - http://ebm.bmj.com/content/9/5/142.abstract N2 - Hayden FG, Belshe R, Villanueva C, et al. Management of influenza in households: a prospective, randomized comparison of oseltamivir treatment with or without postexposure prophylaxis. J Infect Dis 2004;189:440–9.OpenUrlAbstract/FREE Full Text 
 
 Q In household contacts (HHCs) (after index influenza [flu] patients received oseltamivir), is postexposure prophylaxis (PEP) more effective than oseltamivir treatment at the time of illness (expectant treatment) for preventing flu transmission? Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Infectious diseases ★★★★★★☆ Design: cluster (household level) randomised controlled trial. Allocation: {concealed}†.* Blinding: unblinded.* Follow up period: 30 days. Setting: households in Europe and North America. Participants: 812 HHCs (age range 1–83 y, 55% girls/women) of index patients with a flu like illness during a community flu outbreak. Eligible households had 3–8 members, including ⩾1 index patient and ⩾2 eligible contacts ⩾1 year of age. Exclusion criteria included pregnancy, breastfeeding, and cancer. Intervention: households were allocated to PEP (n = 138 households with 410 HHCs) or expectant treatment (n = 139 … ER -