TY - JOUR T1 - Sildenafil improved erectile dysfunction and quality of life in men with comorbid mild to moderate depression JF - Evidence Based Medicine JO - Evid Based Med SP - 121 LP - 121 DO - 10.1136/ebm.7.4.121 VL - 7 IS - 4 A2 - , Y1 - 2002/07/01 UR - http://ebm.bmj.com/content/7/4/121.abstract N2 - (2001) Am J Psychiatry 158, 1623; Seidman SN, Roose SP, Menza MA, et al.. Treatment of erectile dysfunction in men with depressive symptoms: results of a placebo-controlled trial with sildenafil citrate.. Oct;. :. –30.OpenUrlCrossRefPubMedWeb of Science
 
 QUESTION: In men with erectile dysfunction (ED) and mild-to-moderate depression, does depression affect ED treatment response to sildenafil and does improvement in ED affect depression? Randomised {allocation concealed*}†, blinded {patients, clinicians, data collectors, and outcome assessors}†,* placebo controlled trial with 12 weeks of follow up. 20 urology clinics in the USA. 152 men (mean age 56 y) who had ED for ≥ 6 months (mean duration 6 y); a stable relationship with a female partner for ≥ 6 months; a Diagnostic and Statistical Manual of Mental Disorders, 4th ed, diagnosis of depressive disorder not otherwise specified; and a Hamilton Depression Rating Scale score of ≥ 12. Exclusion criteria included presence of another axis I psychiatric disorder, current use of nitrates or any antidepressant medication, and abnormal serum hormone concentrations. 89% of patients were included in the analysis. 74 men were … ER -