TY - JOUR T1 - Short course nevirapine was better than zidovudine for reducing the risk of mother to child transmission of HIV-1 infection JF - Evidence Based Medicine JO - Evid Based Med SP - 53 LP - 53 DO - 10.1136/ebm.9.2.53 VL - 9 IS - 2 A2 - , Y1 - 2004/03/01 UR - http://ebm.bmj.com/content/9/2/53.abstract N2 - Jackson JB, Musoke P, Fleming T, et al. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month follow-up of the HIVNET 012 randomised trial. Lancet 2003;362:859–68.OpenUrlCrossRefPubMedWeb of Science 
 
 Q In pregnant women with HIV-1 infection, is short course nevirapine more effective than a short zidovudine regimen for reducing the risk of mother to child transmission of HIV-1 infection? Design: randomised controlled trial. Allocation: {concealed}†.* Blinding: {unblinded}†.* Follow up period: 6–8 weeks, 14–16 weeks, and 18 months. Setting: {Mulago hospital in Kampala, Uganda}†. Patients: 626 women who were {⩾18 years of age (mean age 24.5 y) at >32 weeks gestation, tested HIV-1 positive, and lived near the study site. Exclusion criteria included current antiretroviral or HIV-1 immunotherapy, uncontrolled hypertension, haemoglobin concentration <75 g/l, blood creatinine concentration >1.5 mg/dl, blood alanine aminotransferase concentration >3 times the upper limit of normal, and chronic alcohol or illicit drug use.}† Interventions: Of the 313 mothers who were allocated to a 200 mg nevirapine tablet at the onset of labour, … ER -