TY - JOUR T1 - Losartan was more effective than atenolol for isolated systolic hypertension and left ventricular hypertrophy JF - Evidence Based Medicine JO - Evid Based Med SP - 43 LP - 43 DO - 10.1136/ebm.8.2.43 VL - 8 IS - 2 A2 - , Y1 - 2003/03/01 UR - http://ebm.bmj.com/content/8/2/43.abstract N2 - (2002) JAMA 288, 1491. Kjeldsen SE, Dahlöf B, Devereux RB, et al.. Effects of losartan on cardiovascular morbidity and mortality in patients with isolated systolic hypertension and left ventricular hypertrophy: a Losartan Intervention for Endpoint Reduction (LIFE) substudy.. ;. :. –8.OpenUrlCrossRefPubMedWeb of Science
 
 QUESTION: In patients with isolated systolic hypertension (ISH) and left ventricular hypertrophy (LVH), is losartan based therapy more effective than atenolol based therapy? Randomised {allocation concealed*}†, blinded {patients, clinicians, data collectors, outcome assessors, data analysts, and manuscript writers}†,* controlled trial with mean 4.7 year follow up. 945 outpatient settings in Europe and the US. 1326 patients between 55 and 80 years of age (mean age 70 y, 60% women) with ISH (sitting blood pressure [BP] 160–200 mm Hg systolic and <90 mm Hg diastolic after 1–2 wk of placebo) and electrocardiographic signs of LVH. … ER -