TY - JOUR T1 - A topical cream containing glucosamine and chondroitin sulphate reduced joint pain in osteoarthritis of the knee JF - Evidence Based Medicine JO - Evid Based Med SP - 154 LP - 154 DO - 10.1136/ebm.8.5.154 VL - 8 IS - 5 A2 - , Y1 - 2003/09/01 UR - http://ebm.bmj.com/content/8/5/154.abstract N2 - (2003) J Rheumatol 30, 523. Cohen M, Wolfe R, Mai T, et al.. A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee.. ;. :. –8.OpenUrlAbstract/FREE Full Text
 
 QUESTION: In patients with osteoarthritis of the knee, is a topical cream containing glucosamine sulphate, chondroitin sulphate, and camphor more effective than placebo for relieving joint pain? Randomised (allocation concealed*), blinded (patients, healthcare providers, and data collectors)*, controlled trial with 8 weeks of follow up. An outpatient clinic at Monash Medical Center, Australia. 63 patients with objectively documented osteoarthritis of the knee who had had knee pain rated >4 cm on a 10 cm visual analogue scale in one or both knees for >4 weeks. Exclusion criteria included women of childbearing age who were not using contraception or were pregnant, and patients who had a regular requirement for analgesia for conditions unrelated to osteoarthritis or had used oral or topical glucosamine in the previous 6 weeks. Follow up was 94% (mean age 63 y, 54% women). Patients were allocated … ER -