TY - JOUR T1 - No consistent evidence to date that prenatal or postnatal probiotic supplementation prevents childhood asthma and wheeze JF - Evidence Based Medicine JO - Evid Based Med SP - 144 LP - 144 DO - 10.1136/eb-2014-101721 VL - 19 IS - 4 AU - Michael D Cabana Y1 - 2014/08/01 UR - http://ebm.bmj.com/content/19/4/144.abstract N2 - Commentary on: Azad MB, Coneys JG, Kozryrskyj AL, et al. Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis. BMJ 2013;347:f6471. Probiotics are ‘live microorganisms, that when administered in adequate amounts, confer a health benefit on the host’.1 Based on the hygiene hypothesis and the potential effects of probiotics on the developing microbiota of the infant, it is thought that early probiotic supplementation might help decrease the likelihood of wheeze or asthma in children.2 ,3 Results from several clinical trials have been mixed. This systematic review and meta-analysis examines the effectiveness of prenatal and postnatal probiotic supplements for the primary prevention of asthma or childhood wheeze. This study reviewed randomised controlled … ER -