TY - JOUR T1 - Beyond genetics: focusing on maternal environment for congenital heart disease prevention JF - Evidence Based Medicine JO - Evid Based Med SP - e8 LP - e8 DO - 10.1136/eb-2013-101556 VL - 19 IS - 2 AU - Vidu Garg AU - Madhumita Basu Y1 - 2014/04/01 UR - http://ebm.bmj.com/content/19/2/e8.abstract N2 - Commentary on: Liu S, Joseph KS, Lisonkova S, et al. Association between maternal chronic conditions and congenital heart defects: a population-based cohort study. Circulation 2013;128:583–9.OpenUrlAbstract/FREE Full Text Congenital heart disease (CHD) is the most common birth defect, accounting for about one-quarter of birth defects resulting in mortality.1 Aetiology for the majority of CHD remains unknown, but is thought to be multifactorial with genetic and environmental (non-genetic) contributors. Advances in molecular biology and genetic technologies have aided identification of genetic contributors for CHD. Increasing numbers of genomic abnormalities have been discovered in individuals with CHD using next-generation sequencing and array-based methodologies.2 While great strides have been made, genetic aetiologies are identified in only a subset of CHD.2 Epidemiological studies have demonstrated associations … ER -