TY - JOUR T1 - CALORIES trial offers confirmatory evidence that parenteral nutrition does not cause infectious complications in critically ill patients JF - Evidence Based Medicine JO - Evid Based Med SP - 60 LP - 60 DO - 10.1136/ebmed-2014-110132 VL - 20 IS - 2 AU - Gordon S Doig AU - Fiona Simpson Y1 - 2015/04/01 UR - http://ebm.bmj.com/content/20/2/60.abstract N2 - Commentary on: Harvey SE, Parrott F, Harrison DA, et al.; CALORIES Trial Investigators. Trial of the route of early nutritional support in critically ill adults. N Engl J Med 2014;371:1673–84.OpenUrlCrossRefPubMedWeb of ScienceCritically ill patients are hypermetabolic and have increased nutritional requirements. Major international guidelines promote early enteral nutrition (EN), however, up to 35% of all patients remain unfed 3 or more days after intensive care unit (ICU) admission.1 EN is delayed because clinicians believe it is poorly absorbed in critical illness and because they believe excess vomiting may lead to pneumonitis. Parenteral nutrition (PN), an intravenous solution containing glucose, amino acids and lipids, is intuitively appealing because it avoids perceived complications related to gastric dysfunction while providing necessary calories and protein.A meta-analysis of clinical trials comparing PN with EN … ER -