TY - JOUR T1 - Weight loss ≥10% is required by the severely obese to achieve minimal clinically important differences in health-related quality of life JF - Evidence Based Medicine JO - Evid Based Med SP - 69 LP - 69 DO - 10.1136/ebmed-2014-110129 VL - 20 IS - 2 AU - Amy Elizabeth Rothberg Y1 - 2015/04/01 UR - http://ebm.bmj.com/content/20/2/69.abstract N2 - Commentary on: Warkentin LM, Majumdar SR, Johnson JA, et al. Weight loss required by the severely obese to achieve clinically important differences in health-related quality-of-life: two-year prospective cohort study. BMC Med 2014;12:175.OpenUrlCrossRefPubMedAmong the severely obese, weight loss of 5–10% produces clinically important improvements in cardiometabolic risk and health. Whether this degree of weight loss produces meaningful improvements in health-related quality of life (HRQOL) is unclear. This study determined the amount of weight loss required to achieve minimal clinically important difference (MCID), defined as the smallest change in HRQOL that a patient would identify as beneficial, as measured by three validated instruments.This 2-year, prospective observational study enrolled 500 severely obese patients (body mass index, BMI ≥35 kg/m2) just after they entered a particular phase of the programme: 150 were waitlisted (WL), 200 medically managed (MM) and 150 received bariatric surgery (BS). Patients progressed sequentially, so all BS patients previously … ER -