TY - JOUR T1 - In knee osteoarthritis, pharmacological interventions, with the exception of acetaminophen, significantly improve pain; with intra-articular administration being more effective JF - Evidence Based Medicine JO - Evid Based Med SP - 173 LP - 173 DO - 10.1136/ebmed-2015-110182 VL - 20 IS - 5 AU - Bryan M Saltzman AU - Kirk A Campbell Y1 - 2015/10/01 UR - http://ebm.bmj.com/content/20/5/173.abstract N2 - Commentary on: Bannuru RR, Schmid CH, Kent DM, et al. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med 2015;162:46–54.OpenUrlCrossRefPubMedKnee osteoarthritis (OA) is a progressive degenerative disease affecting many individuals worldwide. Owing to high disease burden and increasing healthcare costs, the relative efficacy of different treatment options have been extensively studied.1 ,2 There have been numerous studies comparing effectiveness of various medications including acetaminophen, anti-inflammatories, intra-articular (IA) corticosteroids, IA-hyaluronic acid (HA), and oral and IA-placebo. This systematic review and network meta-analysis examined randomised controlled trials (RCTs) comparing different treatments for knee OA in order to determine the best treatment option.A systematic review of RCTs of patients with symptomatic primary knee OA that compared at least two interventions and reported data for … ER -