TY - JOUR T1 - Lung cancer screening with low-dose CT: benefits and potential risks JF - Evidence Based Medicine JO - Evid Based Med SP - 108 LP - 109 DO - 10.1136/eb-2012-100926 VL - 18 IS - 3 AU - Nichole T Tanner AU - Gerard A Silvestri Y1 - 2013/06/01 UR - http://ebm.bmj.com/content/18/3/108.abstract N2 - Commentary on: Bach PB, Mirkin JN, Oliver TK, et al. Benefits and harms of CT screening for lung cancer: a systematic review. JAMA 2012;307:2418–29.OpenUrl Lung cancer is the leading cause of cancer death worldwide.1 The majority of patients present with advanced disease and the current 5-year survival is only 15%.2 Previous research showed no mortality benefit to screening with chest radiography and sputum cytology. The recent results of the National Lung Screening Trial (NLST) are the first to show a significant reduction in lung cancer mortality with the use of low-dose CT (LDCT) in high risk individuals. The potential for harm with screening and generalisability of results have been a cause for concern in initiation of lung cancer screening programmes. As such, a multisociety collaborative initiative was undertaken to develop the foundation for a clinical guideline for lung cancer screening. The authors performed a literature search using MEDLINE, EMBASE and the Cochrane Library databases … ER -