TY - JOUR T1 - Intravenous immunoglobulin plus corticosteroids prevent coronary artery abnormalities in Kawasaki disease JF - Evidence Based Medicine JO - Evid Based Med SP - 217 LP - 218 DO - 10.1136/eb-2013-101264 VL - 18 IS - 6 AU - Paul Brogan AU - Michael Levin Y1 - 2013/12/01 UR - http://ebm.bmj.com/content/18/6/217.abstract N2 - Commentary on: Chen S, Dong Y, Yin Y, et al. Intravenous immunoglobulin plus corticosteroid to prevent coronary artery abnormalities in Kawasaki disease: a meta-analysis. Heart 2013;99:76–82.OpenUrlAbstract/FREE Full Text Kawasaki disease (KD) is a medium vessel vasculitis affecting approximately 8 of 100 000 children under the age of 5 per year in the UK. It is the commonest cause of acquired heart disease in children in developed countries.1 The cause remains elusive. KD is associated with coronary artery aneurysms (CAA) in over 20% of untreated patients; intravenous immunoglobulin (IVIG) reduces CAA frequency to 5%. Only 2–3% of untreated cases die as a result of coronary vasculitis, and KD is an important cause of long-term cardiac disease in … ER -