TY - JOUR T1 - Uncertainty remains about early pregnancy outcomes after treatment for cervical intraepithelial neoplasia JF - Evidence Based Medicine JO - Evid Based Med SP - 72 LP - 72 DO - 10.1136/ebmed-2014-110136 VL - 20 IS - 2 AU - Kristyn Mary Manley AU - Tim Draycott Y1 - 2015/04/01 UR - http://ebm.bmj.com/content/20/2/72.abstract N2 - Commentary on: Kyrgiou M, Mitra A, Arbyn M, et al. Fertility and early pregnancy outcomes after treatment for cervical intraepithelial neoplasia: systematic review and meta-analysis. BMJ 2014;349:g6192.OpenUrlAbstract/FREE Full TextThe introduction of a cervical screening programme has reduced the overall mortality rate from cervical cancer by 60% in the UK, mainly through pre-emptive treatment of the precursor lesion, cervical intraepithelial neoplasia (CIN).1 ,2 Each year, 22 430 women will have excisional or ablative treatments for CIN and many of these women will be of reproductive age.2 Previous studies have reported an increased risk of preterm labour (<37 weeks) and lower birth weight (<2500 g) following excisional treatments for CIN.3 However, there is limited data relating to the effects on conception and first and second trimester outcomes.MEDLINE and EMBASE searches were conducted. Stated outcomes were overall rates of miscarriage, first trimester (<12 weeks) … ER -