TY - JOUR T1 - Catheter-directed thrombolysis prevents post-thrombotic syndrome in patients with acute deep vein thrombosis in the upper half of the thigh JF - Evidence Based Medicine JO - Evid Based Med SP - 182 LP - 183 DO - 10.1136/ebmed-2012-100673 VL - 17 IS - 6 AU - Anthony J Comerota Y1 - 2012/12/01 UR - http://ebm.bmj.com/content/17/6/182.abstract N2 - Commentary on: Enden T, Haig Y, Kløw NE, et al. Long-term outcome after additional catheter-directed thrombolysis versus standard treatment for acute iliofemoral deep vein thrombosis (the CaVenT study): a randomised controlled trial. Lancet 2012;379:31–8.OpenUrlCrossRefPubMedWeb of Science Post-thrombotic syndrome (PTS) can be a debilitating consequence of acute deep venous thrombosis (DVT). The subset of patients with iliofemoral DVT represents a particularly high-risk cohort of patients likely to develop PTS.1 Anatomically, the common femoral, external iliac and common iliac veins represent the single venous outflow tract from the lower extremity and, when acutely occluded, result in high venous and compartment pressures.2 Sustained venous hypertension, specifically ambulatory venous hypertension, is the underlying pathophysiology of chronic post-thrombotic venous disease. Treatment strategies which eliminate clot and restore unobstructed venous drainage to the vena cava have resulted in … ER -