TY - JOUR T1 - Cotrimoxazole is associated with sudden death in older patients receiving inhibitors of renin–angiotensin system JF - Evidence Based Medicine JO - Evid Based Med SP - 113 LP - 113 DO - 10.1136/ebmed-2014-110133 VL - 20 IS - 3 AU - Raya E Kheirbek AU - Nawar Shara Y1 - 2015/06/01 UR - http://ebm.bmj.com/content/20/3/113.abstract N2 - Commentary on: Fralick M, Macdonald EM, Gomes T, et al. Canadian Drug Safety and Effectiveness Research Network. Co-trimoxazole and sudden death in patients receiving inhibitors of renin-angiotensin system: population based study. BMJ 2014;349:g6196OpenUrlAbstract/FREE Full Text.ACE inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are commonly prescribed to older patients with hypertension, heart failure (HF) and chronic kidney disease (CKD) and may increase serum potassium (K) levels. Cotrimoxazole, a common antibiotic used to treat urinary tract infections, may also raise serum K levels, especially in patients also taking other drugs that raise serum K … ER -