TY - JOUR T1 - Varenicline may reduce negative effect while aiding smoking cessation JF - Evidence Based Medicine JO - Evid Based Med SP - 23 LP - 23 DO - 10.1136/eb-2013-101435 VL - 19 IS - 1 AU - J Taylor Hays Y1 - 2014/02/01 UR - http://ebm.bmj.com/content/19/1/23.abstract N2 - Commentary on: Cinciripini PM, Robinson JD, Karam-Hage M, et al. Effects of varenicline and bupropion sustained-release use plus intensive smoking cessation counseling on prolonged abstinence from smoking and on depression, negative affect, and other symptoms of nicotine withdrawal. JAMA Psychiatry 2013;70:522–33.OpenUrlCrossRefPubMedWeb of Science Cigarette smoking remains the most important cause of preventable morbidity and premature mortality, with projected annual tobacco-attributable deaths worldwide estimated to reach nearly 6.5 million by 2015.1 The most effective treatment for tobacco dependence is combined behavioural and pharmacological therapy, which is widely available yet underemployed. Most attempts to quit smoking are still unaided, and surveys suggest that pharmacological treatment is often not used optimally.2 Even when used effectively, most attempts to quit smoking with pharmacological support still result in relapse … ER -