TY - JOUR T1 - Inhaled anticholinergic medications in older men with chronic obstructive pulmonary disorder are associated with increased odds of acute urinary retention JF - Evidence Based Medicine JO - Evid Based Med SP - 60 LP - 61 DO - 10.1136/ebm.2011.100143 VL - 17 IS - 2 AU - Robert Kyskan AU - Don D Sin Y1 - 2012/04/01 UR - http://ebm.bmj.com/content/17/2/60.abstract N2 - Commentary on: Stephenson A, Seitz D, Bell CM, et al. Inhaled anticholinergic drug therapy and the risk of acute urinary retention in chronic obstructive pulmonary disease: a population-based study. Arch Intern Med 2011;171:914–20.OpenUrlCrossRefPubMedWeb of Science Chronic obstructive pulmonary disease (COPD) affects 1 in 10 individuals more than 40 years of age.1 Many of these patients use inhaled anticholinergic (IAC) medications, often as a first-line therapy.2 Although IACs are generally poorly absorbed from the gastrointestinal and respiratory tracts, approximately 10–15% of the drug make it into the systemic circulation.3 Cholinergic receptors are expressed in prostatic tissue, and their stimulation may cause urinary retention.4 However, the risk of acute urinary retention (AUR) related to IAC use in the older COPD population is not known. This was a population-based nested case-control study from Ontario, Canada, in which the risk of AUR was compared between … ER -