TY - JOUR T1 - Metformin associated with better cardiovascular outcomes than other glycaemic therapies JF - Evidence Based Medicine JO - Evid Based Med SP - 103 LP - 103 DO - 10.1136/eb-2013-101682 VL - 19 IS - 3 AU - Zachary T Bloomgarden Y1 - 2014/06/01 UR - http://ebm.bmj.com/content/19/3/103.abstract N2 - A question exists as to whether the outcome of glycaemic treatment of diabetes varies with the agent used; speculation surrounds whether metformin might be preferable to other treatments. Ghotbi and colleagues performed an epidemiological analysis of 8192 obese patients with diabetes at increased cardiovascular risk participating in the Sibutramine Cardiovascular OUTcomes (SCOUT) trial. Mortality and a combined cardiovascular outcome of non-fatal myocardial infarction, non-fatal stroke, resuscitation after cardiac arrest or cardiovascular death were compared among those receiving one of the following interventions: no pharmacological glycaemic treatment, metformin monotherapy, insulin monotherapy, sulfonylurea monotherapy, metformin plus sulfonylurea and metformin plus insulin. Each group consisted of approximately 1000–1500 participants, randomised to either sibutramine or control (the main purpose of the trial) and followed up to 6 years. The authors performed … ER -