TY - JOUR T1 - Ranitidine use is associated with increased morbidity and mortality in very low birthweight infants JF - Evidence Based Medicine JO - Evid Based Med SP - 36 LP - 37 DO - 10.1136/ebmed-2012-100622 VL - 18 IS - 1 AU - C Michael Cotten AU - William F Malcolm Y1 - 2013/02/01 UR - http://ebm.bmj.com/content/18/1/36.abstract N2 - Commentary on: Terrin G, Passariello A, De Curtis M, et al. Ranitidine is associated with infections, necrotizing enterocolitis, and fatal outcome in newborns. Pediatrics 2012;129:e40–5.OpenUrlAbstract/FREE Full Text Gastroesophageal reflux (GER) is the retrograde movement of stomach contents into the oesophagus. Pharmacotherapy aimed at reducing problems attributed to GER includes histamine receptor blockers (H2 blockers), such as ranitidine, which reduce stomach acidity. Extremely preterm infants often exhibit clinical signs consistent with GER,1 and GER medications are among the most commonly prescribed medications in neonatal intensive care units (NICUs).2 Approximately one third of extremely premature (<28 weeks gestation), very low birthweight (VLBW; <1500 g) infants acquire infections during their NICU stay. Necrotising enterocolitis (NEC), a serious intestinal morbidity in preterm infants, occurs in approximately 10%. About half … ER -